Séminaire Institut

Mercredi 31 Mars 2010 à 14h00.

Equilibrium and non-equilibrium DNA dynamics

''exceptionnellement le séminaire du LPMCN est programmé ce mercredi Theoretical approaches to DNA dynamics rely on a combination of simulations, continuum modeling and scaling approaches. - The local dynamics of DNA is scale dependent and exhibits elastic effects, entropic effects and center-of-mass dynamics as one goes from smaller to larger scales, in accordance with recent fluorescence-correlation spectroscopy data and with measurable consequences for the binding rate of peptides to DNA. - In modern single-molecule studies of protein unfolding DNA functions as force-transducer. Extracting protein folding landscapes and transition rates requires deconvolution of the experimental data and thus knowledge of the dynamic response of DNA chains. - A DNA polymer that is continuously rotated at one end exhibits a critical rotational frequency, at which the dominant hydrodynamic dissipation mode changes from speedometer-cable-like axial spinning to a loop creation/diffusion mode. This is relevant for in-vivo DNA replication and transcription processes. - Global cross-over dynamics of single semiflexible polymers M. Hinczewski and R. R. Netz, EPL, 88 (2009) 18001 - Plectoneme creation reduces the rotational friction of a polymer H. Wada and R.R. Netz, EPL, 87 (2009) 38001''