We are working on cellular biology issues (single cell and multicellular mechanics, adhesion, motility and tumor escape) with biophysical approaches on models such as embryonic multicellular spheroids, breast and prostate cancer cells, Dictyostelium Discoideum. They also works on membrane physics in the context of biolubrication and sonoporation using supported phospholipids bilayers.

We are involved in both fundamental projects (cell-cell adhesion, collective cell migration, rheological properties of tissues, cell-cell interactions) and applied projects (role of lipid membranes in biolubrication, sonoporation, phenotypic sorting of cancer cells, development of lab-on-a-chips using confined tumor spheroids or cancer cells for drug screening …).

Physics of Cancer

What is the role of tumor physical environment and cell mechanical properties in cancer development?

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Tissue Mechanics

How do assemblies of cells deform, exchange neighbors under stress?

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Cell Motility

Quantify cell migration to better understand embryonic morphogenesis, wound repair and cancer invasion.

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Physics of Membranes

 

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Methods Developments

Tools developped to quantify biological processes

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Contact

Jean Paul RIEU  - Institut Lumière et Matière - Université Claude Bernard Lyon 1 et CNRS - Bâtiment Brillouin, 43 Boulevard du 11 Novembre - 69622 Villeurbanne Cedex. France - jean-paul.rieu at univ-lyon1.fr - Phone: +33-(0)4 72 43 11 42 - Fax: +33-(0)4 72 43 26 48