Grand Séminaire d'Institut

Jeudi 28 Mars 2024 à 11h30.

Metabolic in-vivo optical sensing with NIRS: MetaboLight

''My work is interdisciplinary and distinctive as it crosses from technology development in optical neuroimaging (devices, algorithms) to applications (clinical, neuroscience) to data analytics towards generating information and knowledge (computational models, machine learning). I will talk about my pioneering work that starts from the development of optical broadband-NIRS instrumentation and algorithms for monitoring non-invasively brain tissue changes in oxygenation and metabolism (the oxidation state of cytochrome-c-oxidase or oxCCO); through to establishing a clinical broadband-NIRS bedside system in the neonatal intensive care unit (NICU); and finally demonstrating via clinical studies and computational analytics that broadband-NIRS measurement of brain tissue oxCCO, measured as early as the first day of life in newborns with hypoxic-ischaemic encephalopathy (HIE) can prognosticate neurodevelopment. Hence demonstrating beyond the proof-of-principle stage how my optical technologies have a direct impact on identifying within hours after birth neonatal brain injury and support clinical decisions. Beyond these developments I will also briefly introduce our neuroimaging work with broadband-NIRS in understanding the role of mitochondrial in driving\supporting the functional haemodynamic response and brain activity.

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