Grand Séminaire d'Institut

Vendredi 27 Septembre 2024 à 11h00.

Simulating Different Hypothesis for Cell Segregation

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Throughout the seminar, I will provide an overview of our work on cell segregation phenomena within the framework of active matter. The initial literature on cell segregation dates back to the last century and proposed various hypotheses to explain the phenomenon, such as differential adhesion between cells of different tissues, variations in cell cortex tension, and differences in cell velocities. These hypotheses began to be tested through computer simulations in the 1990s, starting with a Potts model approach (Glazier-Graner-Hogeweg) and later, around the year 2000, with a finite differences method (Brodland).

I will begin by presenting simulations within the context of active matter, specifically using Vicsek-like particles interacting with two different intensities of adhesion forces. Subsequently, we ran similar simulations with identical adhesion forces but varying velocities. More recently, by using rings composed of active particles connected by springs to represent cells, we explored the hypothesis of differential tension as a segregation mechanism. In this context, we developed a more theoretical approach, extending previous mean cluster models used in binary mixtures to include active particles. This allows us to relate the different time scales observed in cluster growth during segregation with cell alignment.

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