Séminaire

Vendredi 14 Novembre 2025 à 11h00.

Poly(2-oxazoline)s for drug delivery: lipid nanocapsules, micelles, AuNPs

Oksana KRUPKA
(Université d'Angers)

Salle de séminaires Lippmann

Invité(e) par
Vladimir LYSENKO

présentera en 1 heure :

''Résumé / Abstract :
Poly(2-alkyl-2-oxazoline)s (POx) have been attracting attention of researchers due to their possibility to combine biocompatibility with stealth behavior, making them ideal candidates for use in a wide variety of biomedical applications.
In this presentation we will underline the chemical tools for the design of poly(2-oxazoline)s based Drug Delivery Systems (DDS).
Specifically, we will present a greener synthetic approach that gives a simple and more environmentally friendly route to synthesizing gold nanoparticles (AuNPs) for biomedical applications. In this presentation, we will detail a novel one-step, green synthesis of POx-coated AuNPs, which eliminates the need for additional reducing and stabilizing agents and the potential of NPs against aggressive brain tumour.
We will show possibility to modulate the interaction of the POx-micelles with tumor cells.
Finally, we will underscore the potential of heavy-atom-free photosensitizer (HAF-PS) loaded lipid nanocapsules (LNC) PEG-LNC/ POx-LNC as highly efficient, targeted nanocarriers for photodynamic therapy (PDT), as safer and effective cancer therapies with minimization of side effects.
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