Séminaire

Vendredi 20 Septembre 2019 à 11h00.

Microfluidic experiments of cellular behaviors under hypoxic exposure

''L'équipe Biophysique invite Kenichi Funamoto de l'Institute of Fluid Science, Tohoku University, Sendai, Japan; actuellement chercheur invité CNRS 2019.
Abstract: In a microenvironment /in vivo/, cells are exposed to spatial and temporal heterogeneity of oxygen tension. Therefore, it is essential to understand cell behaviors under hypoxic condition for elucidation of mechanisms of diseases. My research group has developed microfluidic devices with controllability of oxygen tension for cellular experiments. Using the developed devices, behaviors of cancer cells and vascular endothelial cells and their cell-cell interactions were investigated under controlled oxygen tension. Hypoxic exposure induced an increased proliferation and an enhanced migration of cancer cells. It also increased permeability and collective migration of vascular endothelial monolayer. Changes of extracellular matrix caused by cell-cell interaction were also found to be oxygen-dependent.''