Séminaire

Vendredi 14 Mars 2025 à 11h00.

Roles of intercellular adhesion and mechanical perturbations as structuration factors of biomimetic emulsions

''
In this talk I will present the work developed during my PhD. taking inspiration from the feedback loops between bio-chemical signaling and mechanical cues at play during morphogenesis as well as the adhesion hierarchy driven self-organization properties of cells, we aimed at describing the sole influence of extrinsic forces and cellular adhesion on the mechanical behavior of biological tissues.
In order to work in a simplified framework, we used adhesive emulsions as a biomimetic system of epithelial tissues, in which each oil droplet mimics a cell in the tissue and differentials of adhesion are introduced using palindromic DNA sequences as the binders between the droplets. We then flowed the obtained “proto-tissues” in micro-channels of various geometry that directly define the applied stress field.
We experimentally and theoretically showed the influence of local droplet deformations and T1 events on the global behavior of the emulsion flow and correlated those observations to the evolving structure of the emulsion along the channel as a function of the interdroplet adhesion hierarchy.

''