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Jean-Paul Rieu (Professor) |
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Hélène Delanoë-Ayari (Assistant Professor)I am trying to understand how mechanics impact embryogenesis and to quantify how cells and assemblies of cells do react when submitted to stress. For that I am deforming cellular aggregates inside microchannels and observing cell deformation and neighbor exchanges using two photons microscopy. |
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Charlotte Rivière (Assistant Professor)My work focus on the analysis of cell dynamics in controled micro-environement, at both single and multicellular scale. key words : Physics of Cancer, Dictyostelium Discoideum, Microsystems, Cell Motility |
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Thomas Dehoux (CNRS Researcher, Team Leader)I use acoustic and opto-acoustic techniques to study the mechanics and tribology of biological matter. My current research topics include contact mechanics probed with acoustic waves, thermal imaging of cells and rheology and tribology of cells. Website: http://ilm-perso.univ-lyon1.fr/~tdehoux/ |
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Sylvain Monnier (Assistant Professor)My work focuses on the mechanics of biological systems. Mechanical cues play important roles in numerous fundamental biological processes. More specifically, we are interested in the control of cell size at the single cell and multicellular levels under physiological and pathological constraints. We develop quantitative approaches and microfluidic tools in order to understand how mechanics can affect growth and gene expression. website |
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Olivier Cochet-Escartin (CNRS Researcher, Team Leader)My work focuses on the mechanical aspects of Hydra regeneration. Animal regeneration is a rare but fascinating phenomenon that bears ressemblance with the development of organisms from a single cell. However, our understanding of regeneration remains limited because of a lack of understanding of the importance of mechanical cues in this process. I therefore develop microfluidics and soft matter approaches to mechanically perturb a regenerating Hydra in order to understand its response at the molecular, patterning and regenerative scales. |
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Christophe Anjard (Professor) |
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Maroun Abi-Ghanem (CNRS Researcher)My research focuses on the design of self-assembled and biologically-derived phononic materials. Man-made, dynamically-responsive composites, often referred to as phononic crystals and metamaterials, are well-known for their unique effective properties that provide radical new ways to manipulate the propagation of elastic waves. However, challenges remain with respect to their democratization and fabrication in large quantities at the micro- and nanoscales. Using biological composites to design phononic materials is a potential solution, in the context of nature's capacity for rapidly self-assembling, en masse, complex multi-scale structures. |
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Stéphane Joly (CNRS Biological Engineer)My activity consists in implementing cell and molecular biology techniques for research activities related to the role of mechanics on biological processes involved in cancer, development and regeneration as well as cell motility studies on various biological systems. |
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Lorraine Montel (CNRS Researcher)I'm interested in how immune cells perceive and react to their mechanical environment. Particularly, I aim to understand how macrophages can recognize and ingest dying cells to clean our tissues, and especially the role of mechanics in this process. I use emulsion droplets decorated with lipids to mimick the physical and chemical properties of dying cells that are ingested by macrophages, to investigate how these properties impact the recognition of dying cells. I also use magnetic microbeads to apply forces on the macrophages and measure their mechanical properties, to learn more on how internal forces modifiy the gene expression and inflammatory state of macrophages. |
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Claire Dessalles (CNRS Researcher)I study the dynamics and mechanics of biological tissues, specifically thin sheets of cells in a 3D geometry, with a focus on the role of activity and anisotropy. I grow cellular monolayers in complex in vitro systems, such as a microstretcher to characterize the tissue rheology, or microshells of alginate, to manipulate the tissue geometry and topology. |
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Morgane Roinard (Project Engineer)I am a studies engineer in cellular/molecular biology and microfabrication. My work focuses on microfluidic systems development aimed at mimicking an oxygen gradient on colorectal cancer organoids. Using microfluidic techniques and 3D cell culture, I model biological systems at the microscopic scale to study the complex interactions between tumor cells and surrounding tissues and thus better understand the phenomena of tumor resistance. |
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Colin Rosewicz (Study Engineer)I evaluate how differently sized and charged fluorescently labeled polymers distribute through tumor spheroids and where they accumulate within cells (e.g., membrane/cytoplasm/nucleus) via confocal imaging and image analysis. |
Microfabrication Platform: |
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Alpha Diallo (Research Engineer iLM/CRCL)I am in charge of the µFab microfabrication platform at the CRCL (8 av. rockfeller) whose main objective is to help and support researchers wishing to turn to new types of in vitro models allowing to better control the cell environment in 2D or 3D (adhesion, flow, mechanical constraints). For example, it allows the creation of Agarose microwells for the culture of cells in 3D (spheroids, organoids) with a high degree of statistics during sampling and a good reproducibility. This type of microsystem also reduces the amount of biological samples needed, offers great possibilities of parallelization, facilitates observations and in-situ monitoring under microscopes, or the collection of specific cells. The platform provides existing molds (made at ILM by photolithography, 3D printing or micromachining). I can also help you in the CAD design and fabrication of custom micro-devices, answering your biological problematic. Keywords : microfabrication, microfluidic device design, 3D printing. |
Postdocs: |
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Estelle BastienI am currently Postdoctoral researcher in the Institute of Light and Matter (iLM), where I studied molecular pathway and biomechanics events implicated in cellular morphological signature (cell-swelling) of pyroptosis cell- death, with Dr. Sylvain Monnier. I gained expertise in tumor microenvironment and its implication on tumor development and therapy resistance, over my previous postdoctoral fellow in Experimental and Research Institute (IREC), UCLouvain, with Pr. Olivier Feron (Brussel, Belgium). I obtained my PhD focusing on the development of new photoactivable anticancer nanoparticles, under the supervision of Dr. Lina Bezdetnaya and Dr. Henri-Pierre Lassalle (Nancy, France). |
Rabia Onbas
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PhD Students: |
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Lucie VovardMy aim is to understand and characterize how molecular crowding act as a common regulator of biomechanical and biomolecular properties in cells using Brillouin Light Scattering.. |
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Juliette CodevelleMy PhD is part of the ANR-funded project IMITATE. Using agarose-based microsystems, my PhD aims to develop a robust analytical pipeline to investigate the interplay between metabolic states, overall growth dynamics, and in situ cell behavior within three-dimensional colorectal tumor spheroid models. |
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Loan TricaudThe aim of my study is to investigate the phononic and piezoelectric properties of plants. By exploiting the metamaterial behaviour of plant microstructures, we hope to improve the conversion of ultrasound energy into electrical energy. |
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Boutheina ReghisMy work focuses on efferocytosis, a key process for tissue homeostasis and inflammation resolution. By developing biomimetic lipid droplets mimicking dying cells, I analyze how their mechanical properties, such as deformability and divisibility, affect macrophage internalization. This research combines biophysics, cell biology, and microscopy to explore the role of mechanical forces and the cytoskeleton in this process.. |
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Lou-Anne Goutier
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Lucas BoistayI investigate an emergent form of active micro-phase separation in Dictyostelium discoideum, where self-generated oxygen gradients give rise to collective, coordinated, and persistent dynamics of motile cellular aggregates. |
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Malaury Devissi
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Former members:
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