Group members:

Jean-Paul Rieu (Professor, Team Leader)

Hélène Delanoë-Ayari (Assistant Professor)

I am trying to understand how mechanics impact embryogenesis and to quantify how cells and assemblies of cells do react when submitted to stress. For that I am deforming cellular aggregates inside microchannels and observing cell deformation and neighbor exchanges using two photons microscopy.

Charlotte Rivière  (Assistant Professor)

My work focus on the analysis of cell dynamics in controled micro-environement, at both single and multicellular scale.

key words : Physics of Cancer, Dictyostelium Discoideum, Microsystems, Cell Motility

Thomas Dehoux (CNRS Researcher, Team Leader)

I use acoustic and opto-acoustic techniques to study the mechanics and tribology of biological matter. My current research topics include contact mechanics probed with acoustic waves, thermal imaging of cells and rheology and tribology of cells.


Sylvain Monnier (Assistant Professor)

My work focuses on the mechanics of biological systems. Mechanical cues play important roles in numerous fundamental biological processes. More specifically, we are interested in the control of cell size at the single cell and multicellular levels under physiological and pathological constraints. We develop quantitative approaches and microfluidic tools in order to understand how mechanics can affect growth and gene expression. 


Olivier Cochet-Escartin (CNRS Researcher)

My work focuses on the mechanical aspects of Hydra regeneration. Animal regeneration is a rare but fascinating phenomenon that bears ressemblance with the development of organisms from a single cell. However, our understanding of regeneration remains limited because of a lack of understanding of the importance of mechanical cues in this process. I therefore develop microfluidics and soft matter approaches to mechanically perturb a regenerating Hydra in order to understand its response at the molecular, patterning and regenerative scales.

I also work on modelling and numerical simulations of biological phenomena through the application of continuum mechanics and cellular Potts model. Finally, I develop neural networks and deep learning models to help in the analysis of various experiments on a need by need basis.

Key words: mechanobiology, regeneration, pattern formation, modelling, image analysis

Christophe Anjard (Professor)

Maroun Abi-Ghanem (CNRS Researcher)

My research focuses on the design of self-assembled and biologically-derived phononic materials. Man-made, dynamically-responsive composites, often referred to as phononic crystals and metamaterials, are well-known for their unique effective properties that provide radical new ways to manipulate the propagation of elastic waves. However, challenges remain with respect to their democratization and fabrication in large quantities at the micro- and nanoscales. Using biological composites to design phononic materials is a potential solution, in the context of nature's capacity for rapidly self-assembling, en masse, complex multi-scale structures.

Stéphane Joly (CNRS Biological Engineer)

My activity consists in implementing cell and molecular biology techniques for research activities related to the role of mechanics on biological processes involved in cancer, development and regeneration as well as cell motility studies on various biological systems.

Lorraine Montel (CNRS Researcher)

I'm interested in how immune cells perceive and react to their mechanical environment. Particularly, I aim to understand how macrophages can recognize and ingest dying cells to clean our tissues, and especially the role of mechanics in this process. I use emulsion droplets decorated with lipids to mimick the physical and chemical properties of dying cells that are ingested by macrophages, to investigate how these properties impact the recognition of dying cells. I also use magnetic microbeads to apply forces on the macrophages and measure their mechanical properties, to learn more on how internal forces modifiy the gene expression and inflammatory state of macrophages.


Microfabrication Platform:

Alpha Diallo (Research Engineer iLM/CRCL)

I am in charge of the µFab microfabrication platform at the CRCL (8 av. rockfeller) whose main objective is to help and support researchers wishing to turn to new types of in vitro models allowing to better control the cell environment in 2D or 3D (adhesion, flow, mechanical constraints). For example, it allows the creation of Agarose microwells for the culture of cells in 3D (spheroids, organoids) with a high degree of statistics during sampling and a good reproducibility. This type of microsystem also reduces the amount of biological samples needed, offers great possibilities of parallelization, facilitates observations and in-situ monitoring under microscopes, or the collection of specific cells. The platform provides existing molds (made at ILM by photolithography, 3D printing or micromachining). I can also help you in the CAD design and fabrication of custom micro-devices, answering your biological problematic. Keywords : microfabrication, microfluidic device design, 3D printing.



Artem Husiev

I am interested in development of the new and improvement of the existing opto-acoustical methods of the study of material properties in nano- and micrometric scales. Currently, my research is focused on the biological metamaterials.

Estelle Bastien

I am currently Postdoctoral researcher in the Institute of Light and Matter (iLM), where I studied molecular pathway and biomechanics events implicated in cellular morphological signature (cell-swelling) of pyroptosis cell- death, with Dr. Sylvain Monnier. I gained expertise in tumor microenvironment and its implication on tumor development and therapy resistance, over my previous postdoctoral fellow in Experimental and Research Institute (IREC), UCLouvain, with Pr. Olivier Feron (Brussel, Belgium). I obtained my PhD focusing on the development of new photoactivable anticancer nanoparticles, under the supervision of Dr. Lina Bezdetnaya and Dr. Henri-Pierre Lassalle (Nancy, France).


PhD Students:

Adrien Carrère (PhD Student)

My work focuses on the study of one aggregation phase of Dictyostelium Discoideum an uni-cellular organism that under some condition (most commonly starvation) can regroup to form a more or less complex multi-cellular structure to assure is survival.

Julie Hesnard

My work focuses on the determination of genes involved in the migration toward oxygen, a phenomenon that called aerotaxis. For that, I work on Dictyostelium discoideum mutants and I try to characterise their phenotype of migration depending on oxygen concentrations.

Gaëtan Jardiné

My work focuses on the role of diffusion and cellular volume on cell fate in tissues. How do compressive stresses affect diffusion in the extra-cellular matrix and spatial distribution of volume ? Can we link diffusion and volume distributions to cell fate in models of cancer tissues ?

Nasser Ghazi

My research project focuses on the dynamics of single cells in hypoxic environments - a main example being the collective behavior arising from self-generated oxygen gradients.

Thomas Perros

My work focuses on the study of the role of physical stimuli on the regeneration of organisms. For this purpose, the Hydra, a freshwater polyp capable of completely reforming every excised part of its body, is used as a model organism. This study involves the use of microfluidic and molecular biology tools.

Lucie Vovard

My aim is to understand and characterize how molecular crowding act as a common regulator of biomechanical and biomolecular properties in cells using Brillouin Light Scattering..


Former members:

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